Cardiology MCQ 380: Bivalirudin
Bivalirudin
a) Bivalirudin is a synthetic 20 amino acid polypeptide
b) Inactivates both free and fibrin bound thrombin
c) Useful in HITS
d) All of the above
["Click here for the answer with explanation", "Correct Answer:"]
d) All of the above
Bivalirudin is a synthetic 20 amino acid polypeptide – interacts bivalently with both active catalytic site and exosite 1 of thrombin.
Inactivates both free and fibrin bound thrombin
Short half life of 25 minutes – confers a potential safety advantage
Half life may be increased in renal failure
Useful in HITS (Heparin Induced Thrombocytopenia Syndrome)
ISAR-REACT 3, REPLACE-2, ACUITY and HORIZONS-AMI Trials have shown the efficacy of Bivalirudin.
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Source: Cardiophile MD - Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs