Maintenance of a healthy trajectory of the intestinal microbiome during aging: A dietary approach

Publication date: March–April 2014 Source:Mechanisms of Ageing and Development, Volumes 136–137 Author(s): Marco Candela , Elena Biagi , Patrizia Brigidi , Paul W. O’Toole , Willem M. De Vos Sharing an intense transgenomic metabolism with the host, the intestinal microbiota is an essential factor for several aspects of the human physiology. However, several age-related factors, such as changes diet, lifestyle, inflammation and frailty, force the deterioration of this intestinal microbiota–host mutualistic interaction, compromising the possibility to reach longevity. In this scenario, the NU-AGE project involves the development of dietary interventions specifically tailored to the maintenance of a healthy trajectory of the intestinal microbiome, counteracting all processes connected to the pathophysiology of the human aging. Graphical abstract
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research