Fosfomycin: mechanisms and the increasing prevalence of resistance.

Fosfomycin: mechanisms and the increasing prevalence of resistance.
J Med Microbiol. 2018 Nov 15;:
Authors: Aghamali M, Sedighi M, Zahedi Bialvaei A, Mohammadzadeh N, Abbasian S, Ghafouri Z, Kouhsari E
Abstract
There are challenges regarding increased global rates of microbial resistance and the emergence of new mechanisms that result in microorganisms becoming resistant to antimicrobial drugs. Fosfomycin is a broad-spectrum bactericidal antibiotic effective against Gram-negative and certain Gram-positive bacteria, such as Staphylococci, that interfere with cell wall synthesis. During the last 40 years, fosfomycin has been evaluated in a wide range of applications and fields. Although numerous studies have been done in this area, there remains limited information regarding the prevalence of resistance. Therefore, in this review, we focus on the available data concerning the mechanisms and increasing resistance regarding fosfomycin.
PMID: 30431421 [PubMed - as supplied by publisher]

Source: Journal of Medical Microbiology - November 15, 2018 Category: Microbiology Authors: Aghamali M, Sedighi M, Zahedi Bialvaei A, Mohammadzadeh N, Abbasian S, Ghafouri Z, Kouhsari E Tags: J Med Microbiol Source Type: research