Effect of GnRHa on Th17/Treg cells in peripheral blood of patients with unexplained repeated implantation failure

ConclusionThere were an increase and a decrease in the number of Th17 and Treg cells, respectively, with Th17/Treg cells imbalanced in unexplained RIF. GnRHa downregulation may play a direct immunomodulatory role in disrupting the imbalance and then improve the endometrial receptivity. These effects did not depend on the E2 levels in peripheral blood, nor affect early embryonic development.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research