One ‐Step Synthesis of Iodinated Polypyrrole Nanoparticles for CT Imaging Guided Photothermal Therapy of Tumors

A one ‐step synthesis strategy is proposed for the fabrication of iodinated polypyrrole (I ‐PPy) nanoparticles via a smart combined chemical oxidation and iodination method. The I‐PPy nanoparticles not only guarantee remarkable contrast‐enhanced computed tomography (CT) imaging of blood pool and tumors, but also realize effective tumor theranostics via I‐PPy nanoparticles‐mediat ed CT imaging‐guided photothermal therapy. AbstractTheranostic materials are of great significance to a personalized precise medicine. However, conventional theranostic agents are mainly fabricated by combining presynthesized independent imaging probes and therapeutic agents, suffering from multiple synthesis procedures, poor morphological control, and time/reagent ‐consuming process. Herein, iodinated polypyrrole (I‐PPy) nanoparticles are fabricated via a one‐step synthesis strategy combining chemical oxidation and iodination for computed tomography (CT) imaging‐guided photothermal therapy. Iodic acid with a high standard electrode potential enables t he chemical oxidation polymerization of pyrrole monomers. Meanwhile, the iodination of PPy induced by the corresponding reduction product I2 takes place during the polymerization process to generate I ‐PPy nanoparticles. The prepared I‐PPy nanoparticles possess a uniform size, excellent colloidal stability, intense near‐infrared absorption, strong X‐ray attenuation ability, and favorable biocompatibility. The as‐synthesiz...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research