Acute pancreatic beta cell apoptosis by IL-1β is responsible for postburn hyperglycemia: Evidence from humans and mice

ConclusionsOur findings reveal a novel mechanism of acute hyperglycemia postburn in which impaired insulin secretory capacity mediated by IL-1β leads to acute hyperglycemia. These data suggest that targeting IL-1β to restore endogenous insulin secretory function may be a novel glycemic control strategy to improve outcomes for burn patients.Graphical abstract

Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - November 11, 2018 Category: Molecular Biology Source Type: research