P083 - Study of TMPRSS2-ETS molecular translocations in prostate cancer by fluorescence in-situ hybridization and real time polymerase chain reaction and its correlation with clinical and biochemical parameters

Publication date: November 2018Source: European Urology Supplements, Volume 17, Issue 14Author(s): S. Menon, S. Balagangadharan, O. Shetty, P. Bapat, S.B. Desai
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research

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Publication date: Available online 9 December 2019Source: Reports of Practical Oncology &RadiotherapyAuthor(s): A. Zapatero, M. Adrados, L. Torres, M.S. Talaya, A. Cruz Conde, C. Martin de Vidales, L. Vega Piris, C. Olivier, M.T. MurilloABSTRACTBackground/aim(s)To determine the impact of post-treatment biopsy results on 10-year metastasis-free survival (MFS), overall survival (OS) and cause-specific survival (CSS) in localized prostate cancer (PCa) patients treated with high-dose radiotherapy (RT).Materials/MethodsRetrospective analysis of 232 patients with T1c-T3bN0M0 PCa who underwent a prostate biopsy 24–36 mo...
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
Conclusion: Our results were not able to show any significant correlation between increasing convenience with QUANTEC limits and lower rectal toxicity. Conclusively, new dosimetric definitions are warranted to predict acute rectal toxicity more accurately in prostate cancer patients during IMRT treatment.
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
Noncanonical Wnt as a prognostic marker in prostate cancer: "You can't always get what you Wnt". Expert Rev Mol Diagn. 2019 Dec 07;: Authors: Fisher RR, Pleskow HM, Bedingfield K, Miyamoto DT Abstract Introduction: Wnt signaling is important for normal development, cell proliferation, and cell differentiation. However, aberrations in the pathway can lead to tumorigenesis and cancer progression. Recent genome-wide studies have demonstrated the frequent occurrence of Wnt pathway alterations in prostate cancer. Although alterations in the canonical Wnt pathway in prostate cancer may have an impa...
Source: Expert Review of Molecular Diagnostics - Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research
Conclusion: The investigation revealed germline and somatic mutated genes associated with indolent and aggressive PCas and distinguishing the two types of PCa. The study revealed multiple gene regulatory networks and signaling pathways dysregulated by germline and somatic alterations. Integrative analysis combining germline and somatic mutations is a powerful approach to mapping germline and somatic mutation interaction landscape. PMID: 31814827 [PubMed]
Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research
lncRNA PCAT-1 interacting with FZD6 contributes to the malignancy of acute myeloid leukemia cells through activating Wnt/β-catenin signaling pathway. Am J Transl Res. 2019;11(11):7104-7114 Authors: Yuan Y, Wang Q, Ma SL, Xu LQ, Liu MY, Han B, Du N, Sun XL, Yin XL, Cao FF Abstract Accumulating evidence has suggested the involvement of long noncoding RNAs (lncRNAs) on the acute myeloid leukemia (AML). Therefore, this study aimed to investigate the unknown function of lncRNA Prostate cancer-associated transcript-1 (PCAT-1) in AML cells. Our data found that PCAT-1 was highly expressed in AML-M1/2 and ...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Authors: Mabonga L, Kappo AP Abstract Small nuclear ribonucleoprotein polypeptide G (SNRPG), often referred to as Smith protein G (SmG), is an indispensable component in the biogenesis of spliceosomal uridyl-rich small nuclear ribonucleoprotein particles (U snRNPs; U1, U2, U4 and U5), which are precursors of both the major and minor spliceosome. SNRPG has attracted significant attention because of its implicated roles in tumorigenesis and tumor development. Suggestive evidence of its varying expression levels has been reported in different types of cancers, which include breast cancer, lung cancer, prostate cancer ...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Healthcare insurance companies should value PET imaging and its cost-effective...Read more on AuntMinnie.comRelated Reading: CMS final rule for MPFS could cost radiology $5B CMS gets pushback on PET fee cuts PSMA-PET/CT most effective for recurrent prostate cancer Editorial slams NRC plan to expand radiopharmaceutical users PET tracers help guide breast cancer therapies
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Future Oncology, Ahead of Print.
Source: Future Oncology - Category: Cancer & Oncology Authors: Source Type: research
Contributors : Tianqi Wu ; Jianhua WangSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo explore the role of HIC1 deletion in regulating prostate cancer(PCa) microenvironment development, Human Gene Expression Microarrays were searched for altered genes upon HIC1 knockout expression in PC3 cells. According to fold-change screening between HIC1-knockout and its respective control cells, both up-regulated and down-regulated genes were shown.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Contributors : John W Phillips ; Yang Pan ; Brandon L Tsai ; Zhijie Xie ; Levon Demirdjian ; Wen Xiao ; Harry T Yang ; Yida Zhang ; Chia H Lin ; Donghui Cheng ; Douglas L Black ; Owen N Witte ; Yi XingSeries Type : Expression profiling by high throughput sequencing ; Third-party reanalysisOrganism : Homo sapiensWe sought to define the landscape of alternative pre-mRNA splicing in prostate cancers and the relationship of exon choice to known genetic driver alterations. To do so, we compiled a meta-dataset comprised of RNA-Seq samples from publicly available sources representing a range of phenotypes from normal tissue to dr...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Third-party reanalysis Homo sapiens Source Type: research
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