Schizophrenia Polygenic Risk Score as a Predictor of Antipsychotic Efficacy in First-Episode Psychosis.

CONCLUSIONS:: Patients with higher PRS for schizophrenia tended to have less improvement with antipsychotic drug treatment. PRS burden may have potential utility as a prognostic biomarker.
PMID: 30392411 [PubMed - as supplied by publisher]

Source: The American Journal of Psychiatry - November 5, 2018 Category: Psychiatry Authors: Zhang JP, Robinson D, Yu J, Gallego J, Fleischhacker WW, Kahn RS, Crespo-Facorro B, Vazquez-Bourgon J, Kane JM, Malhotra AK, Lencz T Tags: Am J Psychiatry Source Type: research