Bile Acids Increased after RYGB in Chinese Patients Could be Potential Contribution to Improved Glucose and Lipid Metabolism

Background: The multifactorial mechanisms promoting weight loss and improved metabolism following Roux-en-Y gastric bypass (RYGB) surgery remain incompletely understood. Recent rodent studies suggest that bile acids can mediate energy homeostasis by activating the G-protein coupled receptor TGR5 and the type 2 thyroid hormone deiodinase. Altered gastrointestinal anatomy following RYGB could affect enterohepatic recirculation of bile acids.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Source Type: research