Role of adverse pathological features in surgically treated early oral cavity carcinomas with adequate margins and the development of a scoring system to predict local control

Head&Neck, EarlyView.
Source: Head and Neck - Category: ENT & OMF Authors: Source Type: research

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Authors: Shay E, Sangwan N, Padmanabhan R, Lundy S, Burkey B, Eng C Abstract The etiology of head and neck squamous cell carcinoma (HNSCC) is not fully understood. While risk factors such as positive human papilloma virus (HPV) status, smoking and tobacco use have been identified, they do not account for all cases of the disease. We aimed to characterize the bacteriome, mycobiome and mycobiome-bacteriome interactions of oral wash in HNSCC patients and to determine if they are distinct from those of the oral wash of matched non-HNSCC patients. Oral wash samples were collected from 46 individuals with HNSCC and 46 co...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
This article reports a case of glandular odontogenic cyst in a 70-year-old male and discusses the clinical, radiological and histopathological features. The present case shows treatment of GOC which effected the body of mandible with infiltration into submandibular gland.
Source: Journal of Maxillofacial and Oral Surgery - Category: ENT & OMF Source Type: research
AbstractBackgroundDocetaxel, cisplatin, and 5-fluorouracil (TPF) induction chemotherapy (ICT) is a treatment option for locally advanced unresectable head and neck squamous cell carcinoma (LA-HNSCC). However, patients with advanced age, or renal, cardiac or neurogenic dysfunction are ineligible for ICT-TPF.MethodsWe retrospectively assessed 24 unresectable LA-HNSCC patients who received paclitaxel, carboplatin and cetuximab (PCE) as ICT at the Shizuoka Cancer Center between April 2013 and October 2018.ResultsPatient characteristics were as follows: median age, 72  years (range 60–81); 0, 1, and 2 performance sta...
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
Buchwald C Abstract BACKGROUND: The incidence of oral cancer is approximately 300,000 patients annually. A cancer diagnosis and treatment affect both physical and mental issues. OBJECTIVES: The aim of this systematic review was to examine the development of depression in patients who have been treated for oral squamous cell carcinoma (OSCC). MATERIAL AND METHODS: PubMed and EMBASE were systematically searched for studies addressing depression among patients treated for OSCC and published within the past ten years. RESULTS: We identified three studies comprising 528 patients (range: 75-349), primari...
Source: Acta Oto-Laryngologica - Category: ENT & OMF Authors: Tags: Acta Otolaryngol Source Type: research
AbstractA 73 ‐year‐old man presented with a history of a non‐healing socket associated with persistent pain and swelling and enlarged submandibular lymph nodes two months after a mandibular implant extraction. His symptoms persisted despite repeated antibiotic therapy. Biopsy from the non‐healing extract ion socket and core needle biopsy (CNB) of the right level I lymph node was initially reported as a poorly differentiated carcinoma as it expressed CK7 only. Further investigation with PET‐CT imaging revealed FDG avidity above and below the diaphragm with the left axillary lymph node, the most pro minent and acce...
Source: Oral Surgery - Category: ENT & OMF Authors: Tags: CASE REPORT Source Type: research
miR‑144‑3p inhibits tumor cell growth and invasion in oral squamous cell carcinoma through the downregulation of the oncogenic gene, EZH2. Int J Mol Med. 2020 Aug;46(2):828-838 Authors: He L, Liao L, Du L Abstract Accumulating evidence demonstrates that microRNAs (miRNAs or miRs) play important roles in the development and progression of human malignancies, including oral squamous cell carcinoma (OSCC); however, the unique roles of miRNAs are not yet fully understood in OSCC. The present study aimed to identify novel miRNAs associated with OSCC and to elucidate their functions. Based on a mic...
Source: International Journal of Molecular Medicine - Category: Molecular Biology Authors: Tags: Int J Mol Med Source Type: research
Long non‑coding RNAs are novel players in oral inflammatory disorders, potentially premalignant oral epithelial lesions and oral squamous cell carcinoma (Review). Int J Mol Med. 2020 Aug;46(2):535-545 Authors: Zhang K, Qiu W, Wu B, Fang F Abstract In recent years, a large number of studies have shown that the abnormal expression of long non‑coding (lnc)RNAs can lead to a variety of different diseases, including inflammatory disorders, cardiovascular disease, nervous system diseases, and cancers. Recent research has demonstrated the biological characteristics of lncRNAs and the important funct...
Source: International Journal of Molecular Medicine - Category: Molecular Biology Authors: Tags: Int J Mol Med Source Type: research
Publication date: Available online 7 July 2020Source: American Journal of OtolaryngologyAuthor(s): Melanie D. Hicks, Diana Lin, Erin P. Buczek
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
In this study, sex chromosome analysis was performed in patients with oral squamous cell carcinoma (OSCC) that developed after hematopoietic stem cell transplantation from the opposite gender to examine whether OSCC originates from bone marrow (BM) stem cells. Gene expression patterns in patients with possible BM stem cell-derived OSCC were compared with those in patients with normally developed OSCC.We used microarray analysis to examine whether OSCC with a possible BM origin shows specific pattern of the gene expression.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Madam — It is common practice to avoid contralateral neck dissections for non-central oral cavity squamous cell carcinomas (OCSCC). In our series [1], 27/101 patients underwent bilateral neck dissections, of whom only five did not receive bilateral adjuvant neck radiotherapy; no sentinal node biopsies w ere carried out. Therefore, these data do not inform on the safety of omitting contralateral neck radiotherapy following surgical contralateral neck staging.
Source: Clinical Oncology - Category: Radiology Authors: Tags: Letter Source Type: research
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