Loss of EfnB1 in the osteogenic lineage compromises their capacity to support hematopoietic stem/progenitor cell maintenance

The hematopoietic stem/progenitor cell (HSPC) niche is composed of diverse cellular components that contribute to HSPC maintenance and niche function within the bone marrow. These include arterioles, sinusoidal endothelial cells, Nestin+ mesenchymal stem cells, stromal populations including bone marrow stromal stem cells/perivascular reticular cells, and cells of the osteogenic lineage [1 –9]. These cells are key mediators of hematopoietic stem cell (HSC) maintenance, proliferation, differentiation, and maturation, acting in a non-cell-autonomous manner through membrane-dependent or soluble chemokines and growth factors.

Source: Experimental Hematology - October 13, 2018 Category: Hematology Authors: Agnieszka Arthur, Thao M. Nguyen, Sharon Paton, Andrew C.W. Zannettino, Stan Gronthos Source Type: research