Dioic acid glycosides, tannins and methylated ellagic acid glycosides from Morella salicifolia bark

Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Edna E. Makule, Birgit Kraus, Guido Jürgenliemk, Jörg Heilmann, Stefan WiesnethAbstractThe bark of Morella salicifolia (Hochst.exA. Rich.) Verdc. &Polhill (Myricaceae) is a common herbal drug and especially utilized by the Maasai community of northeastern Tanzania. It is traditionally used to treat swellings on the cheek and face, cough, toothache, stomach problems, headaches, and skin diseases. Unless, there is still a lack of information considering the specialized metabolites that may be responsible for the traditional use of this medicinal plant. An isolation study on a methanolic extract revealed three methylated ellagic acids, castalagin, two monomeric flavan-3-ols, three prodelphinidins and three dioic acid glycosides. Among these metabolites, myriside (3,4-dimethyl ellagic acid 4′-O-β-d-xylopyranoside, 1), epigallocatechin-3-O-gallate-(2β→O→7, 4β→8)-gallocatechin (9), 2,7-dimethyl-8-O-(6′-O-galloyl)-β-d-glucopyranoside-deca-2E,4E-dienedioic acid (10), 2,7-dimethyl-8-O-β-d-glucopyranoside-deca-2E,4E-dienedioic acid (11) as well as 4,9-dimethyl-10-O-β-d-glucopyranoside-dodeca-2E,4E,6E-trienedioic acid (12) were isolated for the first time. To the best of our knowledge, the dioic acid glycosides represent a generally novel structure type. To provide comprehensive information on the condensed tannins, the polymeric proanthoc...
Source: Phytochemistry Letters - Category: Chemistry Source Type: research

Related Links:

Test your medicine knowledge with the  MKSAP challenge, in partnership with the American College of Physicians. A 19-year-old man is hospitalized with a 6-day history of lightheadedness and nightly fevers. He also reports sore throat, headache, joint and muscle aches, and a dry cough. He recalls a blotchy rash on his trunk and arms, w hich has resolved. […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Infectious Disease Source Type: blogs
Publication date: Available online 6 November 2019Source: Respiratory Medicine Case ReportsAuthor(s): Serao Mattia, Marianna Lilli, Angela Succu, Tiziana Trequattrini, Rossana Vigliarolo, Giuseppina Gioffrè, Rosario Rivitti, Aldo Ciani, Shakib Zyada, Silvia Candia, Maria Cristina ZappaAbstractHistoplasma capsulatum is a dimorphic fungus, non-endemic in Italy but endemic in America, Asia and tropical Africa. People who generally visit an endemic area may aspirate spores and run the risk of infection. The aerosolization of micronids or hyphal fragments is considered to cause the epidemic. In most people this fungus, w...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
On 7 October 2019, the National IHR Focal Point of the United Arab Emirates (UAE) notified WHO of one laboratory-confirmed case of Middle East respiratory syndrome coronavirus (MERS-CoV) infection. The patient is a 44-year-old male non-national farmer from Al Ain city, Abu Dhabi region, UAE. He developed fever, runny nose, headache, vomiting, productive cough and shortness of breath on 25 September 2019, and was admitted to hospital on 29 September. A nasopharyngeal aspirate was collected and tested positive for MERS-CoV by reverse-transcriptase polymerase chain reaction (RT-PCR) on 3 October at the Shiekh Khalifa Medical ...
Source: WHO Disease Outbreaks - Category: Infectious Diseases Tags: news Source Type: news
Abstract Purinergic signaling was proposed in 1972, after it was demonstrated that adenosine 5'-triphosphate (ATP) was a transmitter in nonadrenergic, noncholinergic inhibitory nerves supplying the guinea-pig taenia coli. Later, ATP was identified as an excitatory cotransmitter in sympathetic and parasympathetic nerves, and it is now apparent that ATP acts as a cotransmitter in most, if not all, nerves in both the peripheral nervous system and central nervous system (CNS). ATP acts as a short-term signaling molecule in neurotransmission, neuromodulation, and neurosecretion. It also has potent, long-term (trophic) ...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
CONCLUSIONS: Although medical sciences students have information about treatment of illnesses but they should be more informed about negative results and side-effects of self-medication. They should also transfer their knowledge to the society to decrease self-medication behavior. PMID: 31642791 [PubMed - as supplied by publisher]
Source: Current Drug Safety - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Saf Source Type: research
In this study we demonstrate the results of examination of 4,507 people aged over 14 years toward the influenza infection in the epidemic season of 2017/18. Most of the confirmed infections were reported in older people aged over 65, a high-risk population group. A low percentage of the vaccinated population may affect an increased number of confirmed influenza viruses in the elderly. The findings demonstrate a need to increase awareness of vaccination benefits, which is particularly essential to avoid influenza infection in the elderly. PMID: 31559569 [PubMed - as supplied by publisher]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
[Febrile seizures, epilepsy, migraine, diabetes, and heart disease as well as measles, chicken pox, and whooping cough in children and adolescents in Germany : Results from KiGGS Wave 2]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2019 Sep 16;: Authors: Poethko-Müller C, Thamm R, Heidemann C, Busch M, Neuhauser H Abstract Trends of frequent chronic diseases and health problems, e.g. allergic diseases, have already been published based on the KiGGS Wave 2 study as part of the health monitoring of children and adolescents in Germany. The present work complements these ...
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - Category: International Medicine & Public Health Authors: Tags: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Source Type: research
We describe demographic, socioeconomic and clinical characteristics of patients randomized to the same-day initiation arm for both studies. RESULTS AND DISCUSSION: A total of 240 and 296 participants were enrolled in Kenya and South Africa. The majority were female (59% and 64% respectively), with a median age of 35 years. In both countries, most subjects were newly diagnosed with HIV on the day of enrolment (62%, 55%), believed they already had adequate knowledge to begin ART (78%, 68%), and preferred to start ART immediately (same-day) (98% in both countries). About 40% of all patients had at least one symptom r...
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
This article reviews the clinical diagnosis and management of these heterogeneous headaches.
Source: Neurologic Clinics - Category: Neurology Authors: Source Type: research
Stachybotrys chartarum, also known as black mold, is a type of indoor fungus that grows in areas of high moisture and humidity. At high rates of growth, the fungus can produce mycotoxins that become airborne and inhaled. More often than not, inhalation of significant amounts of black mold causes pulmonary mycotoxicosis. Patients present with flu-like symptoms that include fever, chills, nausea, cough, dyspnea, headache, and myalgia. Infections are usually self-limited, requiring only supportive care.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
More News: Complementary Medicine | Cough | Headache | Herbs | Skin | Study | Tanzania Health