Molecular Pathogenesis of the Tauopathies.

Molecular Pathogenesis of the Tauopathies. Annu Rev Pathol. 2018 Oct 24;: Authors: Götz J, Halliday G, Nisbet RM Abstract The tauopathies constitute a group of diseases that have Tau inclusions in neurons or glia as their common denominator. In this review, we describe the biochemical and histological differences in Tau pathology that are characteristic of the spectrum of frontotemporal lobar degeneration as primary tauopathies and of Alzheimer's disease as a secondary tauopathy, as well as the commonalities and differences between the familial and sporadic forms. Furthermore, we discuss selected advances in transgenic animal models in delineating the pathomechanisms of Tau in the different subtypes. Expected final online publication date for the Annual Review of Pathology: Mechanisms of Disease Volume 14 is January 24, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates. PMID: 30355155 [PubMed - as supplied by publisher]
Source: Annual Review of Pathology - Category: Pathology Authors: Tags: Annu Rev Pathol Source Type: research