Transfusion of Platelets Loaded With Recombinant ADAMTS13 (A Disintegrin and Metalloprotease With Thrombospondin Type 1 Repeats-13) Is Efficacious for Inhibiting Arterial Thrombosis Associated With Thrombotic Thrombocytopenic Purpura.

Conclusions- Our results demonstrate that transfusion of rADAMTS13-loaded platelets may be a novel and potentially effective therapeutic approach for arterial thrombosis, associated with congenital and immune-mediated thrombotic thrombocytopenic purpura.
PMID: 30354235 [PubMed - in process]

Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 26, 2018 Category: Cardiology Authors: Abdelgawwad MS, Cao W, Zheng L, Kocher NK, Williams LA, Zheng XL Tags: Arterioscler Thromb Vasc Biol Source Type: research