Status epilepticus: Immunologic and inflammatory Mechanisms of epilepsy

Status epilepticus can be difficult to treat, particularly if refractory, and lead to significant morbidity and mortality. Prolonged seizures are also a risk factor for the subsequent diagnosis of epilepsy. Activation of the immune system and inflammation are areas of recent interest in the field of epilepsy, and there is growing evidence that these may be involved in the pathogenesis of ongoing status epilepticus and subsequent epileptogenesis. We review the current data on this topic in both animal models and human disease.
Source: Seminars in Pediatric Neurology - Category: Neurology Authors: Source Type: research

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In Reply We thank Singh et al for their comments on our article demonstrating the benefits of specialist neurology and comprehensive epilepsy care on mortality in patients with epilepsy. We agree that evidence-based care should be driven by data. In a global environment of accelerating health care costs, the same methods should be used to demonstrate value for money. However, it may be unsurprising that bespoke care improves outcomes; particularly pertinent for countries offering universal health coverage, the unequivocal demonstration of benefit is an indispensable prerequisite for advocates of the judicious use of finite...
Source: JAMA Neurology - Category: Neurology Source Type: research
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Source: JAMA Neurology - Category: Neurology Source Type: research
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Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
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Source: Journal of Neuropsychiatry and Clinical Neurosciences - Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research
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Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
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Source: Seizure - Category: Neurology Source Type: research
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