Atorvastatin Attenuates TNF-alpha Production via Heme Oxygenase-1 Pathway in LPS-stimulated RAW264.7 Macrophages.

CONCLUSION: Atorvastatin can attenuate LPS-induced TNF-α expression and production by activating HO-1 via the ERK and p38 MAPK pathways, suggesting that atorvastatin can be used in treatment of inflammatory diseases such as sepsis, especially in those with atherosclerotic diseases. PMID: 25341814 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/25341814?dopt=Abstract

Source: Biomedical and Environmental Sciences : BES - October 1, 2014 Category: Biomedical Science Authors: Wang XQ, Luo NS, Salah ZQ, Lin YQ, Gu MN, Chen YX Tags: Biomed Environ Sci Source Type: research