An Anti-Tumor Immune Response is Evoked By Partial-Volume Single Dose Radiation in Two Murine Models

The response of tumors subjected to partial irradiation was studied in two different immunocompetent models. A single dose of 10-20Gy of radiation delivered to half the tumor, reproducibly activates an anti-tumor immune response that eliminates the entire tumor. This response is dependent on vascular adhesion molecules that mediate infiltration of cytotoxic T cells.

Source: International Journal of Radiation Oncology * Biology * Physics - October 17, 2018 Category: Radiology Authors: Ela Markovsky, Sadna Budhu, Robert M. Samstein, Hongyan Li, James Russell, Zhigang Zhang, Esther Drill, Chloe Bodden, Qing Chen, Simon N. Powell, Taha Merghoub, Jedd D. Wolchok, John Humm, Joseph O. Deasy, Adriana Haimovitz-Friedman Tags: Biology Contribution Source Type: research