Non-polar lipid carbonyls of thermally oxidized coconut oil induce hepatotoxicity mediated by redox imbalance

Publication date: Available online 16 October 2018Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Arunaksharan Narayanankutty, Anu Anil, Soorya Parathodi Illam, Sruthi Panniyan Kandiyil, Achuthan C. RaghavamenonAbstractThermal oxidation products of edible oils including aldehydes, peroxides and polymerized triglycerides formed during the cooking process is increasingly debated as contributory to chronic degenerative diseases. Depending on the oil used for cooking, the source of fatty acids and its oxidation products may vary and would have a differential influence on the physiological process. Coconut oil (CO) is a medium chain triglyceride-rich edible oil used in South India and other Asia Pacific countries for cooking purposes. The present study evaluated the biological effects of thermally oxidized coconut oil (TCO) as well as its non- polar hexane (TCO-H) and polar methanol (TCO-M) sub-fractions in male Wistar rats. Results showed an increase in the thiobarbituric acid reactive substances (TBARs) and conjugated diene levels in TCO, which extracted to TCO-H fraction. The animals consumed TCO and its hexane and methanol fractions had a considerable increase in weight gain. However, serum and hepatic triglycerides were increased only in animals with TCO and TCO-H administration. In these animals, the hepatic redox balance was disturbed, with a reduction in GSH and a concomitant increase in thiobarbituric acid reactive substances (TBARs). Increased in...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Category: Lipidology Source Type: research

Related Links:

Authors: Norheim AJ, Borud E, Wilsgaard T, De Weerd L, Mercer JB Abstract Exposure to cold climate is an inevitable consequence of military training in Norway. Adequate peripheral microcirculation in the extremities is important to maintain temperature, and to protect against freezing cold injuries. The aim of this study was to investigate the variability in skin rewarming ability. The study subjects consisted of 260 healthy Norwegian army conscripts, following a mild cold provocation test (hands immersed in 20°C water for 1 min) using dynamic infrared thermography (DIRT). Thermal images were obtained to i...
Source: International Journal of Circumpolar Health - Category: International Medicine & Public Health Tags: Int J Circumpolar Health Source Type: research
Authors: Sarrión-Esteve J, Benlloch-Domènech C PMID: 30448054 [PubMed - as supplied by publisher]
Source: Gaceta Sanitaria - Category: International Medicine & Public Health Tags: Gac Sanit Source Type: research
Authors: Frankfurter C, Le J, Cuervo LG Abstract The improvement of health in the twenty-first century is inextricably linked to research for health. In response to growing international appeal to address regional health needs, the Pan American Health Organization (PAHO) and its Member States approved the Policy on Research for Health (CD49/10) in 2009. This document represents the flagship regional policy on research for health and outlines how health systems and services in the region can be strengthened through research. It has been implemented by the two components of PAHO -the Member States and the Pan America...
Source: Gaceta Sanitaria - Category: International Medicine & Public Health Tags: Gac Sanit Source Type: research
CONCLUSIONS: Oncotype is a cost-effective intervention from a health system perspective since each QALY gained costs less than 25,000 euros. From a societal perspective, it is dominant since it provides greater health and is accompanied by cost savings. PMID: 30442434 [PubMed - as supplied by publisher]
Source: Gaceta Sanitaria - Category: International Medicine & Public Health Tags: Gac Sanit Source Type: research
Miriam Kessi, Juan Xiong, Liwen Wu, Lifen Yang, Fang He, Chen Chen, Nan Pang, Haolin Duan, Wen Zhang, Ahmed Arafat, Fei Yin, Jing Peng
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Yvonne H öller, Aljoscha Thomschewski, Andreas Uhl, Arne C. Bathke, Raffaele Nardone, Stefan Leis, Eugen Trinka, Peter Höller
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Mingzhe Zhang, Raynald Liu, Hongli Xing, Huixuan Luo, Leiting Cui, Zhaosheng Sun
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Publication date: Available online 19 November 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Nuria Solà-Valls, Mikel Vicente-Pascual, Yolanda Blanco, Elisabeth Solana, Sara Llufriu, Eloy Martínez-Heras, Elena H. Martínez-Lapiscina, María Sepúlveda, Irene Pulido-Valdeolivas, Irati Zubizarreta, Albert SaizAbstractBackgroundThe Expanded Disability Status Scale (EDSS) and Patient Determined Disease Steps (PDDS) are two of the most widely disability scales used in Multiple Sclerosis (MS). When physical visits are unavailable, remote evaluation through telephone interview may b...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 19 November 2018Source: Brain, Behavior, and ImmunityAuthor(s): Sarah A. Woller, Cody Ocheltree, Stephanie Y. Wong, Anthony Bui, Yuya Fujita, Gilson Gonçalves dos Santos, Tony L. Yaksh, Maripat CorrAbstractIn rheumatoid arthritis, joint pain can persist despite resolution of swelling. Similarly, in the murine K/BxN serum transfer model, a persistent tactile allodynia is observed after the resolution of joint inflammation (post-inflammatory pain) in male mice. Here, we found female wild type (WT) mice show inflammatory, but reduced post-inflammatory tactile allodynia. The transition...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
England ’s most senior nurse is urging eligible people to claim their free flu jab if they haven’t already because surgeries and pharmacies are now fully stocked up.
Source: Nursing Times - Category: Nursing Source Type: news
More News: Coconut Oil | Coconuts | India Health | Lipidology | Study | Toxicology