Preclinical In Vitro and In Vivo Evidence of an Antitumor Effect of CX-4945, a Casein Kinase II Inhibitor, in Cholangiocarcinoma.

CONCLUSION: CX-4945 has an antiproliferative effect on CCA and enhances the effect of gemcitabine and cisplatin through its inhibitory effect on the PI3K/AKT pathway and DNA repair. PMID: 30316146 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30316146?dopt=Abstract

Source: Translational Oncology - October 10, 2018 Category: Cancer & Oncology Authors: Zakharia K, Miyabe K, Wang Y, Wu D, Moser CD, Borad MJ, Roberts LR Tags: Transl Oncol Source Type: research

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