Establishment and characterization of immortalized erythroid progenitor cell lines derived from a common cell source

Recently, attempts have been made to produce large quantities of red blood cells (RBCs) in vitro using cell culture techniques [1-5] Although hematopoietic stem/progenitor cells or pluripotent stem cells have been considered primary candidates for in vitro RBC production, as they possess excellent characteristics for this technology [6-11], we have successfully established immortalized erythroid progenitor cell lines (imERYPCs) that can differentiate into enucleated RBCs [12]. The main advantage of these cell lines is that they can proliferate indefinitely, rapidly produce enucleated RBCs, and can be handled with ease.

Source: Experimental Hematology - October 13, 2018 Category: Hematology Authors: Ryo Kurita, Koji Funato, Takaaki Abe, Yoshihisa Watanabe, Masayuki Shiba, Kenji Tadokoro, Yukio Nakamura, Tadashi Nagai, Masahiro Satake Tags: Brief Communication Source Type: research