Melatonin receptor 1B −1193T > C polymorphism is associated with diurnal preference and sleep habits

Melatonin modulates the master circadian clock through the activation of G-protein-coupled receptors MT1 and MT2. It is presumed, therefore, that genetic variations in melatonin receptors can affect both sleep and circadian phase. We investigated whether the −1193T>C (rs4753426) polymorphism in the promoter of MT2 receptor gene (MTNR1B) is associated with diurnal preference and sleep habits. This polymorphism was previously associated with sunshine duration, suggesting a role in circadian entrainment.

Source: Sleep Medicine - October 13, 2018 Category: Sleep Medicine Authors: Aline Cristine Pereira e Silva, Maria Jos é dos Santos, Bruna Del Vechio Koike, Magna Suzana Alexandre Moreira, Daniel Leite Goes Gitai, Jorge Artur Peçanha de Miranda Coelho, Tiago Gomes de Andrade Source Type: research