Comparison of Changes in the Number of Included Patients Between Interventional Trials and Observational Studies Published from 1995 to 2014 in Three Leading Journals.

DISCUSSION: The routine storage of an increasing amount of data (from data warehouses or claims data) has had an impact in recent years on the number of patients included in observational studies. The recent development of "randomized registry trials" combining, on the one hand, an intervention and, on the other hand, the identification of the outcome through data reuse, may also have an impact, over the next decade, on the number of patients included in randomized clinical trials.
PMID: 30306905 [PubMed - in process]

Source: Studies in Health Technology and Informatics - October 12, 2018 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research