Catalyst-free 1:2 annulation of quinolines with trifluoroacetylacetylenes: a one-pot access to oxazinoquinolines decorated by trifluoromethyl, acetylene and ketone functions

Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02379D, CommunicationBoris Trofimov, Kseniya Belyaeva, Lina Nikitina, Andrei Afonin, A. V. Vashchenko, Vasily Muzalevskiy, Valentine Nenajdenko Metal- and solvent-free reaction of quinolines with two molecules of aryltrifluoroacetylacetylenes afforded 3-arylethynyl-3-trifluoromethyl-1,3-oxazinoquinolines in up to 92% yields. The formation of zwitterionic intermediate at the first step triggered multistep domino... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research