Wright Medical closes $435m Cartiva buy

Wright Medical (NSDQ:WMGI) said today that it closed its $435 million buyout of Cartiva and its synthetic cartilage implant for treating arthritis in the big toe. Alpharetta, Ga.-based Cartiva won pre-market approval from the FDA for the SCI implant in July 2016 (the device won CE Mark approval in the European Union back in 2002 and is also on the market in Canada, Brazil, Chile and Australia). It’s made of an organic polymer designed to mimic the function of human cartilage. Wright announced the deal in August, later floating nearly 18.3 million shares at $24.60 apiece, for expected net proceeds of $423 million, to fund the deal. “We are delighted to welcome Cartiva as a member of the Wright family. With approximately 120,000 procedures for great toe arthritis performed each year in the U.S., we believe that this technology provides a proven alternative to fusion that reduces joint pain without sacrificing the foot’s natural movement and retains mobility and range of motion,” president &CEO Robert Palmisano said in prepared remarks. The post Wright Medical closes $435m Cartiva buy appeared first on MassDevice.
Source: Mass Device - Category: Medical Devices Authors: Tags: Featured Mergers & Acquisitions Orthopedics Wall Street Beat Cartiva Extremities wrightmedical Source Type: news

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Condition:   Chronic Lower Back Pain Intervention:   Device: PICO G2 4k Sponsors:   Cedars-Sinai Medical Center;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In the lumbar spinal cord dorsal horn, release of afferent nerve glutamate activates the neurons that relay information about injury pain. Here, we examined the effects of protein tyrosine kinase (PTK) inhibition on NMDA receptor NR1 subunit protein expression and subcellular localization in an acute experimental arthritis model. PTK inhibitors genistein and lavendustin A reduced cellular histological translocation of NMDA NR1 in the spinal cord occurring after the inflammatory insult and the nociceptive behavioral responses to heat. The PTK inhibitors were administered into lumbar spinal cord by microdialysis, and seconda...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Septic sacroiliitis is a rare and difficult to diagnose infection of the sacroiliac joints [1-3]. Septic sacroiliitis represents 1 –2% of all cases of septic arthritis and the incidence is exceedingly low with only 1–2 cases per year being diagnosed [4,5]. Symptoms of septic sacroiliitis include fever, lower back pain, referred hip pain, and weight-bearing difficulty [6]. Risk factors include trauma, pregnancy, intravenous (IV) drug use, endocarditis, and immunosuppression [7]. Complications resulting from septic sacroiliitis include septic shock, psoas muscle abscess, iliopsoas abscess, long-term joint deformi...
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
Abstract OBJECTIVE: The Western Ontario and McMaster Universities Osteoarthritis (WOMAC) Pain Scale quantifies knee pain severity with activities of daily living, but the potential impact of pain in other body regions on WOMAC pain scores has not been explored using a causal modeling approach. The purpose of this study was to determine if pain in other areas of the body impact WOMAC pain scores, a phenomenon referred to as "cross talk." METHODS: Cross-sectional datasets were built from public use data available from the Osteoarthritis Initiative (OAI) and the Multicenter Osteoarthritis Study (MOST)....
Source: Physical Therapy - Category: Physiotherapy Authors: Tags: Phys Ther Source Type: research
In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation. Lin28 as a Target for Nerve Regeneration https://www.fightaging.org/archives/2020/05/lin28-as-a-target-for-nerve-regeneration/ Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitoch...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study used data from the 2014 –2015 Korea National Health and Nutrition Examination Survey. Survey participants with previous or current osteoarthritis or rheumatoid arthritis, as diagnosed by a doctor, were excluded. OPPs were defined as knee joint pain, hip joint pain, low back pain, and knee stiffness. The cut-off value for SDT was 7.5 hours/day. The study population comprised 3,671 people (1), 856 men and 1,815 women), all of whom were ≥50 years-old. Multiple logistic regression analyses were performed.ResultsA total of 328 men (17.7%) and 519 women (28.6%) had OPPs. Men with SDTs ≥7.5 hours had a grea...
Source: The Journal of Nutrition, Health and Aging - Category: Nutrition Source Type: research
This study demonstrated that crocin significantly increased the mechanical thresholds of adjuvant-induced arthritis (AIA) rats, suggesting that crocin can alleviate neuropathic pain. Crocin significantly decreased the levels of pain-related factors and glial activation. Foxy5, activator of Wnt5a, inhibited the above effects of crocin in AIA rats. In addition, intrathecal injection of a Wnt5a inhibitor significantly decreased hyperalgesia in AIA rats. This research shows that crocin may alleviate neuropathic pain in AIA rats by inhibiting the expression of pain-related molecules through the Wnt5a/β-catenin pathway, elu...
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
OBJECTIVE: To present recent evidence on the prevalence, incidence, costs, activity limitations, and work limitations of common conditions requiring rehabilitation. METHODS: This was a systematic review. Medline (PubMed), SCOPUS, Web of Science, an...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
AbstractCervical spine involvement may lead to severe complications in rheumatoid arthritis (RA). In the era of modern therapies, atlantoaxial subluxation (AAS) may be rare; however, it may still be detected in asymptomatic patients. The onset of myelopathy can occur at any time. Altogether 49 female RA patients were included. Among them, 15 were methotrexate treated, biologic free, while 34 patients received biologics. The patients had no cervical pain or any neurological symptoms. We assessed the first (C1) and second (C2) cervical vertebrae by 3  T magnetic resonance imaging (MRI). In addition to AAS, we also deter...
Source: Rheumatology International - Category: Rheumatology Source Type: research
AbstractTuberculosis (TB) is an important preventable infection in patients with rheumatoid arthritis (RA). To determine the risk of TB in patients with RA by comparing with those with non-specific back pain (NSBP), and to identify the risk factors in the RA group. Medical data were retrieved from a centralized electronic database. A total of 1099 patients with RA and 2489 patients with NSBP were identified. Clinical data, comorbidities, and use of individual disease-modifying anti-rheumatic drugs (DMARDs) were retrieved. Risks of TB in patients with RA and NSBP were compared by propensity score (PS) adjusted analysis with...
Source: Rheumatology International - Category: Rheumatology Source Type: research
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