CSA Medical ices $23m funding round

CSA Medical said yesterday that it put a $23 million debt-and-equity round on ice for the cryospray technology it’s developing. Boston-based CSA said Horizon Technology Finance led the round with a $15 million loan facility; existing shareholders ponied up $8 million in equity financing, the company said. The round’s first tranche included a $6 million loan from Horizon and another $5 million in equity financing from backers including SV Health Investors, Ascension Ventures and Intersouth Partners, CSA said. Proceeds are earmarked for expanding the commercial footprint into gastrointestinal indications for its TruFreeze cryospray and further clinical and regulatory work on its Rejuvenair lung treatment, according to a press release. “Thanks to the support of our existing investors and new partner Horizon, we will continue to expand the market for truFreeze to treat the full spectrum of esophageal diseases including cancer and we will continue to advance Rejuvenair to improve quality of life for COPD patients,” chairman Vincent Owens said in prepared remarks. “This growth capital comes at an exciting moment in CSA’s corporate evolution as the growing body of evidence and patient success stories underscore truFreeze’s critical role in treating a wide range of esophageal disorders,” added TruFreeze president Wendelin Maners. “We are committed to supporting clinical and commercial programs that will dramatically...
Source: Mass Device - Category: Medical Devices Authors: Tags: Featured Funding Roundup Wall Street Beat CSA Medical Inc. Source Type: news

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Conclusions: Mechanical ventilation leads to down-regulation of R-spondin1. R-spondin1 may enhance the interaction of leucine-rich repeat containing G-protein coupled receptor 5 and apoptosis-stimulating protein of p53 2, thus inactivating p53-mediated proapoptotic pathway in cyclic stretched mouse lung vascular endothelial cells. R-spondin1 may have clinical benefit in alleviating mechanical ventilator-induced lung injury.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Online Laboratory Investigation Source Type: research
No abstract available
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Online Erratum Source Type: research
Source: Journal of Biomedical Nanotechnology - Category: Nanotechnology Authors: Tags: Articles Source Type: research
Source: Journal of Biomedical Nanotechnology - Category: Nanotechnology Authors: Tags: Articles Source Type: research
Source: Journal of Biomedical Nanotechnology - Category: Nanotechnology Authors: Tags: Articles Source Type: research
Publication date: Available online 13 June 2019Source: CellAuthor(s): Chien-Hsiang Hsu, Steven J. Altschuler, Lani F. WuSummaryChemotherapy is designed to induce cell death. However, at non-lethal doses, cancer cells can choose to remain proliferative or become senescent. The slow development of senescence makes studying this decision challenging. Here, by analyzing single-cell p21 dynamics before, during, and days after drug treatment, we link three distinct patterns of early p21 dynamics to final cell fate. Surprisingly, while high p21 expression is classically associated with senescence, we find the opposite at early ti...
Source: Cell - Category: Cytology Source Type: research
This study could be beneficial for: (i) Clinicians to receive second opinion from the CAD system for early diagnosis, and (ii) Researchers to analyze and enhance the existing state-of-art techniques used in CAD system, which may further reduce the gap of variability between intra and inter observer.Graphical abstract
Source: IRBM - Category: Biomedical Engineering Source Type: research
Each night millions of patients use continuous positive airway pressure (CPAP) to treat obstructive sleep apnea (OSA). To facilitate monitoring of treatment success, modern CPAP machines routinely record and analyze the respiratory signal in near real-time and submit some of these data to the manufacturer's centralized cloud server. Some of the conditions frequently associated with OSA such as heart failure or chronic obstructive pulmonary disease result in characteristic changes of the respiratory signal (“signatures”), especially during exacerbations. Thus, this infrastructure could be leveraged to detect cha...
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
Contributors : Chang Liu ; Dario A VignaliSeries Type : Expression profiling by arrayOrganism : Mus musculusRegulatory T (Treg) cells are crucial for immune homeostasis but they also contribute to tumor immune evasion by promoting a suppressive tumor microenvironment (TME). Mice with Treg cell-restricted Neuropilin 1 deficiency show tumor resistance while maintaining peripheral immune homeostasis, thereby providing a controlled system to interrogate the impact of intratumoral Treg cells on the TME. Using this and other genetic models, we showed that Treg cells shaped the transcriptional landscape across multiple tumor-infi...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
CSA Medical today released early results from a feasibility study exploring the use of its RejuvenAir Metered Cryospray system in treating patients with chronic bronchitis, touting improvements in quality of life for patients treated with the system. Results from the trial were presented at the 2018 European Respiratory Society Congress in Paris, the Boston-based company said. “We are encouraged by these positive safety and feasibility results and we’re moving forward with plans to initiate a worldwide pivotal study of RejuvenAir in chronic bronchitis in 2019. We look forward to advancing this novel therap...
Source: Mass Device - Category: Medical Devices Authors: Tags: Clinical Trials Respiratory CSA Medical Inc. Source Type: news
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