Chemical Comparison of Prunus africana Bark and Pygeum Products Marketed for Prostate Health

Publication date: Available online 5 October 2018Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Robert Q. Thompson, Daniel Katz, Brendan SheehanAbstractThe bark of Prunus africana may contain atranorin, atraric acid, beta-sitosterol and its esters, ferulic acid and its esters, and N-butylbenzene sulfonamide, compounds that have been shown to improve the conditions of benign prostatic hyperplasia, enlarged prostate. An analytical scheme, involving liquid-solid extractions, saponifications, and LC-APCI-MS (triple quadrupole) analysis, was developed, optimized, and validated to determine the compounds at µg/g levels. Limits of quantification were in the low ng/mL range except for beta-sitosterol. All of the compounds plus two internal standards eluted in under 10 min on a phenyl-hexyl column with gradient elution involving water-methanol and acetonitrile.The mass fraction of the compounds in Prunus africana bark (four samples) and commercial pygeum products (seven samples), derived from bark, were compared. Bark and pygeum were similar in their content of atranorin and atraric acid, found at low µg/g levels, and in the fact that ferulic acid was almost totally (> 90%) in the form of esters. In contrast, the total amount of ferulic acid was on average four times higher in bark (450 µg/g) than in pygeum while the opposite was true for total beta-sitosterol. Some pygeum samples had levels of total beta-sitosterol above 10,000&...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research

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Condition:   Prostatic Hyperplasia Interventions:   Procedure: Holmium laser enucleation of prostate;   Procedure: monopolar transurethral resection of prostate Sponsor:   Ain Shams University Completed
Source: - Category: Research Source Type: clinical trials
Condition:   Benign Prostatic Hyperplasia (BPH) Interventions:   Procedure: Aquablation;   Procedure: HoLEP Sponsor:   Dr. med. Gautier Müllhaupt Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Authors: Murphy N, Shah P, Shih A, Khalili H, Liew A, Zhu X, Lee A Abstract Single-cell sequencing (SCS) is a powerful new tool that applies Next Generation Sequencing at the cellular level. SCS has revolutionized our understanding of tumor heterogeneity and the tumor microenvironment, immune infiltration, cancer stem cells (CSCs), circulating tumor cells (CTCs), and clonal evolution. The following chapter highlights the current literature on SCS in genitourinary (GU) malignancies and discusses future applications of SCS technology. The renal cell carcinoma (RCC) section highlights the use of SCS in characterizing ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
To examine the geographic and pharmacy-type variation in costs for generic benign prostatic hyperplasia (BPH) medications in order to improve drug price transparency and reduce health disparities. Medical therapy for BPH can be expensive, having significant implications for uninsured and underinsured patients.
Source: Urology - Category: Urology & Nephrology Authors: Tags: Health Services Research Source Type: research
Conclusion Anatomic variations are common in internal iliac artery and prostatic artery showing racial and individual differences. Following a standard classification system to identify the origin of the PA is crucial and being aware of the most common types in your population will make PAE a faster and safer procedure. PMID: 32927930 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
This study aims to determine if sBPH is associated with PJI following primary total hip arthroplasty (THA) and total knee arthroplasty (TKA).
Source: The Journal of Arthroplasty - Category: Orthopaedics Authors: Source Type: research
Abstract OBJECTIVE: Benign prostatic hyperplasia (BPH) is an age-related disease, occurring in>70% of men of age>60. Because telomeres and telomerase play a key role in aging and age-related diseases, and certain telomerase gene single nucleotide polymorphisms (SNPs) are shown to be associated with the susceptibility to age-related diseases, we wanted to determine the relationship between BPH and leukocyte telomere length (LTL) and telomere length-related single nucleotide polymorphisms (SNPs) of the telomerase holoenzyme genes. METHODS: Peripheral blood was collected from both BPH patients and age-matc...
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Tags: Int J Clin Exp Pathol Source Type: research
CONCLUSION: Patient-related selection criteria to optimise the UroLift® System clinical outcomes include age, Qmax, PVR urine, median lobe, PSA levels, prostate volume, IPSS and IIEF scores. The UroLift® System is safe and effective in moderate-to-severe BPH refractory to pharmacological treatments and avoids retrograde ejaculation. PMID: 32915085 [PubMed - as supplied by publisher]
Source: Minimally Invasive Therapy and Allied Technologies - Category: Surgery Tags: Minim Invasive Ther Allied Technol Source Type: research
ConclusionsA shift in online interest towards minimally invasive surgical therapies for benign prostatic hyperplasia was demonstrated in the US and worldwide and parallels clinical practice patterns, such as HoLEP and Urolift surgical volumes in Indiana and Australia, respectively. Google Trends can be used in real-time to gauge online interest for surgical procedures and help guide physician –patient counseling.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
ConclusionES-ThuLEP effectively preserved ejaculation in over two thirds of the patients without compromising micturition improvement or erectile function. ES-ThuLEP could be a valid treatment option for BPH in young and sexually active men.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
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