Transactivation of Met signalling by semaphorin4D in human placenta: implications for the pathogenesis of preeclampsia

Conclusion:
The crosstalk between sema4D and Met could transactivate Met to promote trophoblast cell invasion and differentiation, and decreased expression of sema4D and Plexin-B1 may be responsible for the deficiency in Met signalling and the development of preeclampsia.

Source: Journal of Hypertension - October 4, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: Mechanistic aspects Source Type: research