Outcomes of Rectal Cancer Patients With Low Sphincter-Preserving Operations Compared to Patients With Abdominoperineal Resection

AbstractPurpose of ReviewThe surgical management for low rectal cancer patients has evolved as a result of the introduction of preoperative chemoradiotherapy and innovative technical developments. As a result, abdominoperineal resection (APR) for low rectal cancer has decreased over time. Further, the introduction of intersphincteric resection and preoperative chemoradiotherapy has made it possible to proceed with sphincter preservation. However, the oncologic and functional outcomes of intersphincteric resection have been questioned because of the narrow radical margin and sphincter excision. We review the literature to evaluate the oncologic outcomes of sphincter-preserving surgery in low rectal cancer compared to abdominoperineal resection. The oncologic outcome of extended abdominoperineal resection, which was developed to improve result of surgical outcome for low rectal cancer, is also discussed.Recent FindingsThe present manuscript addresses the evidence that shows oncologic safety and acceptable functional outcomes of intersphincteric resection. Our review shows that intersphincteric resection should be considered as an established acceptable operation for the management of low rectal cancer. On the other hand, APR results in frequent positive circumferential margins, higher local recurrence rate compared to sphincter-preserving resection. Nonetheless, abdominoperineal resection was inevitable for some subset of patients; therefore, efforts to improve oncologic outcom...
Source: Current Colorectal Cancer Reports - Category: Cancer & Oncology Source Type: research

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This article is part of a Special Issue entitled: GSK-3 and related kinases in cancer, neurological and other disorders edited by James McCubrey, Agnieszka Gizak and Dariusz Rakus.
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
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Source: Surgery Today - Category: Surgery Source Type: research
Abstract The purpose of this study was to examine if the increased risk of colorectal cancer due to cigarette smoking differed by anatomical subsite and sex. We analyzed data from 188,052 participants (45% men, aged 45-75 years), who were enrolled in the Multiethnic Cohort Study in 1993-1996. During a mean follow-up of 16.7 years, we identified 4,879 incident cases of invasive colorectal adenocarcinoma. In multivariate Cox regression models, compared with never smokers of the same sex, male ever smokers had a 39% [hazard ratio (HR) =1.39; 95% Confidence interval (CI): 1.16,1.67] higher risk of left, but not of rig...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research
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Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
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Source: Asian Journal of Surgery - Category: Surgery Authors: Tags: Asian J Surg Source Type: research
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Source: Acta Diabetologica - Category: Endocrinology Source Type: research
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Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Authors: Li C, Zuo D, Liu T, Yin L, Li C, Wang L Abstract Objective: To assess the association between MUC expression levels in colorectal cancer (CRC) tissues and prognosis and investigate the associations between MUC expression levels and CRC clinicopathological characteristics. Methods: The PubMed, Embase, Cochrane Library, and Web of Science databases were searched from inception through September 13, 2019, to identify studies investigating the association between MUC expression levels in CRC tissues and prognosis. Pooled hazard ratios (HRs) or odds ratio (ORs) with 95% confidence intervals (CIs) were used ...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
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Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
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Source: The American Journal of Surgery - Category: Surgery Source Type: research
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