Rhabdomyolysis secondary to systemic lupus erythematosus

We present a case report of a patient with an SLE exacerbation as well as concurrent rhabdomyolysis with massively elevated CPK (304,700  U/L). Though a rarely reported effect of SLE, rhabdomyolysis can be severe and potentially lethal secondary or concurrent to an acute SLE episode. This case report demonstrates the association between SLE and rhabdomyolysis, which is not well described in the current literature.
Source: Autoimmunity Highlights - Category: Allergy & Immunology Source Type: research

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Publication date: Available online 19 October 2019Source: Autoimmunity ReviewsAuthor(s): David S. Pisetsky, Xavier Bossuyt, Pier Luigi MeroniAbstractSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease with highly variable clinical and immunological manifestations. In the classification of patients with this condition, the presence of an antinuclear antibody (ANA) is an important element, with new criteria from the American College of Rheumatology and European League against Rheumatism positioning ANA positivity by an immunofluorescence assay on HEp2-cells (HEp2-IFA) or by an equivalent solid phase assay a...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
This study included children who were followed regularly in our lupus clinic with proved full house glomerular immune deposits nephritis and antinuclear (ANA), or anti-double-stranded DNA (dsDNA). They were compared with patients who diagnosed with cSLE with and without biopsy proven nephritis, based on Systemic Lupus International Collaborating (SLICC). The comparative group selected by systematic sampling from our cSLE database; the first patient was chosen randomly, and the subsequent patients chosen at intervals of three. The two groups were compared in respect to demographic data, clinical and laboratory findings, and...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Lupus érythémateux systémique. Rev Med Interne. 2019 Sep;40S:S14-S19 Authors: Saadoun D, Desbois AC PMID: 31627799 [PubMed - in process]
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
In this study, we carried out qualitative and quantitative analysis of the donkey whey proteome using a label-free proteomic approach, combined with parallel reaction monitoring (PRM) as a validation method. A total of 300 whey proteins were identified in donkey colostrum (DC) and donkey mature (DM) milk, of which 18 were differentially expressed (P
Source: Food Research International - Category: Food Science Source Type: research
Conclusions: 1. Clinical suspicion of APS requires careful diagnostic testing. Because of inadequate diagnostic workup, many patients may not even have an APS, and these patients could be adequately treated with a DOAC. 2. Patients with single or double positive antiphospholipid antibodies but without positive LA may have a comparably low thrombotic risk and may also be treated with a DOAC in venous TE - sufficient evidence for that conclusion is not yet available but is suggested by the results of meta-analyses. 3. Triple positive patients or those with APS who suffered from arterial thromboembolism have a very high ...
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - Category: Surgery Authors: Tags: Vasa Source Type: research
CONCLUSION: The histomorphological indexes in lupus nephritis are easily obtainable, can predict renal outcomes and may help in the management of such patients. PMID: 31625875 [PubMed - in process]
Source: Acta Medica Portuguesa - Category: General Medicine Tags: Acta Med Port Source Type: research
In conclusion, this preliminary pharmacogenetic study identifies thatCOQ2 gene polymorphism (rs4693075, G  >  C), notTNF- α gene polymorphism (rs1799724, C  >  T), is involved in causing statin-induced myopathy in Bangladeshi hyperlipidemic patients.
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research
ConclusionSerotonin syndrome should be considered in patients on multiple serotonergic agents on the background of end ‐stage renal disease. Prompt recognition and distinction from lupus activity can significantly impact management decisions.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: APLAR GRAND ROUND CASE Source Type: research
CONCLUSION: LN is a very common finding in TRI-positive kidney biopsies. Active LN and chronic LN are the more common classes of TRI-positive LN kidney biopsies, than pure membranous (Class V) LN. TRI positive kidney biopsies without LN are commonly found in diabetic nephropathy, connective tissue disorders and immune mediated GN's. This study highlights this finding in our patients cohort in opposition to what has been reported in the literature. PMID: 30019987 [PubMed - as supplied by publisher]
Source: Ultrastructural Pathology - Category: Pathology Authors: Tags: Ultrastruct Pathol Source Type: research
Conclusion Although hepatic abnormalities caused by daptomycin are rare, a handful of cases with daptomycin-induced liver injury have been reported in the literature. Of note, in most cases, patients on daptomycin therapy developed liver damage with elevations in CK levels. Our case report suggests possible severe liver injury associated with high-dose and long-term daptomycin treatment in the absence of rhabdomyolysis. Future research is warranted to further investigate the relationship between daptomycin use and liver injury, yet it is reasonable to monitor liver function tests at baseline and weekly thereafter along wit...
Source: Journal of Pharmacy Practice - Category: Drugs & Pharmacology Authors: Tags: Adverse Drug Events Source Type: research
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