Rhabdomyolysis secondary to systemic lupus erythematosus

We present a case report of a patient with an SLE exacerbation as well as concurrent rhabdomyolysis with massively elevated CPK (304,700  U/L). Though a rarely reported effect of SLE, rhabdomyolysis can be severe and potentially lethal secondary or concurrent to an acute SLE episode. This case report demonstrates the association between SLE and rhabdomyolysis, which is not well described in the current literature.
Source: Autoimmunity Highlights - Category: Allergy & Immunology Source Type: research

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ConclusionThese results  suggest that miR-1968-5p may be involved in the pathogenesis of lupus nephritis of NZBWF1 mice by targeting csf1.
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
CONCLUSION: The present study explored the potential targets and signaling pathways of curcumin against SLE-ONFH, which could provide a better understanding of its effects in terms of regulating cell cycle, angiogenesis, immunosuppression, inflammation, and bone destruction.PMID:34557547 | PMC:PMC8455200 | DOI:10.1155/2021/5538643
Source: Biomed Res - Category: Research Authors: Source Type: research
CONCLUSION: We found a more severe form of clinical manifestation in pediatric SLE patients at the time of the first presentation in the form of severe renal and extrarenal manifestation compared to other parts of the country.PMID:34558344 | DOI:10.1177/09612033211045069
Source: Lupus - Category: Rheumatology Authors: Source Type: research
CONCLUSIONS: Multiple PIDs can lead to monogenic lupus. Different PID-related monogenic lupus has different suitable targeted drugs.PMID:34559261 | DOI:10.1007/s00011-021-01479-6
Source: Cell Research - Category: Cytology Authors: Source Type: research
J Nephrol. 2021 Sep 24. doi: 10.1007/s40620-021-01144-5. Online ahead of print.NO ABSTRACTPMID:34559399 | DOI:10.1007/s40620-021-01144-5
Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Source Type: research
Kirti Gupta, Gargi Kapatia, Manish Rathi, Suvradeep Mitra, Manphool Singhal, Navneet SharmaIndian Journal of Nephrology 2020 30(5):329-333 Invasive fungal infections are a significant cause of morbidity and mortality in patients systemic lupus erythematosus. The case illustrates the autopsy findings in a patient with systemic lupus erythematosus complicated by multiple fungal infections. Rare, uncommon manifestations of SLE such as mesenteric panniculitis and rhabdomyolysis were also present. High index of suspicion with timely intervention with aggressive antifungal was life-saving.
Source: Indian Journal of Nephrology - Category: Urology & Nephrology Authors: Source Type: research
ConclusionsWe report with a view to recommend autoimmune screening in young patients for whom a cause of rhabdomyolysis is not clearly identified.
Source: International Journal of Emergency Medicine - Category: Emergency Medicine Source Type: research
ConclusionSerotonin syndrome should be considered in patients on multiple serotonergic agents on the background of end ‐stage renal disease. Prompt recognition and distinction from lupus activity can significantly impact management decisions.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: APLAR GRAND ROUND CASE Source Type: research
CONCLUSION: LN is a very common finding in TRI-positive kidney biopsies. Active LN and chronic LN are the more common classes of TRI-positive LN kidney biopsies, than pure membranous (Class V) LN. TRI positive kidney biopsies without LN are commonly found in diabetic nephropathy, connective tissue disorders and immune mediated GN's. This study highlights this finding in our patients cohort in opposition to what has been reported in the literature. PMID: 30019987 [PubMed - as supplied by publisher]
Source: Ultrastructural Pathology - Category: Pathology Authors: Tags: Ultrastruct Pathol Source Type: research
Conclusion Although hepatic abnormalities caused by daptomycin are rare, a handful of cases with daptomycin-induced liver injury have been reported in the literature. Of note, in most cases, patients on daptomycin therapy developed liver damage with elevations in CK levels. Our case report suggests possible severe liver injury associated with high-dose and long-term daptomycin treatment in the absence of rhabdomyolysis. Future research is warranted to further investigate the relationship between daptomycin use and liver injury, yet it is reasonable to monitor liver function tests at baseline and weekly thereafter along wit...
Source: Journal of Pharmacy Practice - Category: Drugs & Pharmacology Authors: Tags: Adverse Drug Events Source Type: research
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