Alerting the Body to Tissue Injury: The Role of Alarmins and DAMPs in Cutaneous Wound Healing

This article will provide an overview of alarmins and outline the latest findings on these mediators in cutaneous wound healing.Recent FindingsIn addition to stimulating inflammatory cells, recent evidence suggests that alarmins can act on other cells in the skin to affect wound closure and the extent of scar tissue production. This review will focus on high-mobility group box-1 and IL-33, two alarmins that have received recent attention in the wound healing field.SummaryBecause a properly regulated inflammatory response is critical for optimal healing, further research must be done to fully understand the role of alarmins in the wound repair process.
Source: Current Pathobiology Reports - Category: Laboratory Medicine Source Type: research