Is it time to routinely incorporate MRD into practice?

Publication date: Available online 21 September 2018Source: Best Practice &Research Clinical HaematologyAuthor(s): Farhad RavandiInterest in detecting minimal/measurable residual disease (MRD) in acute myeloid leukemia (AML) has been increasing, but numerous issues need to be addressed if MRD assessment is to be routinely incorporated into practice. Assays, their reliability, standardization, and availability all must be considered, and a strategy developed to eradicate residual leukemia. This paper reviews some issues surrounding the routine incorporation of MRD assessment into practice.
Source: Best Practice and Research Clinical Haematology - Category: Hematology Source Type: research

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Publication date: Available online 23 August 2019Source: Cancer GeneticsAuthor(s): Chun Hang Au, Dona N. Ho, Beca B.K. Ip, Thomas S.K. Wan, Margaret H.L. Ng, Edmond K.W. Chiu, Tsun Leung Chan, Edmond S.K. MaAbstractDetection of chromosomal translocation is a key component in diagnosis and management of acute myeloid leukemia (AML). Targeted RNA next-generation sequencing (NGS) is emerging as a powerful and clinically practical tool, but it depends on expression of RNA transcript from the underlying DNA translocation. Here, we show the clinical utility of nanopore long-read sequencing in rapidly detecting DNA translocation ...
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
Leukemia, Published online: 23 August 2019; doi:10.1038/s41375-019-0550-5TP53 deficiency permits chromosome abnormalities and karyotype heterogeneity in acute myeloid leukemia
Source: Leukemia - Category: Hematology Authors: Source Type: research
Publication date: Available online 21 August 2019Source: Cancer GeneticsAuthor(s): Nicoletta Coccaro, Luisa Anelli, Paola Orsini, Antonella Zagaria, Angela Minervini, Luciana Impera, Giuseppina Tota, Crescenzio Francesco Minervini, Cosimo Cumbo, Elisa Parciante, Maria Rosa Coserva, Immacolata Attolico, Giorgina Specchia, Francesco AlbanoAbstractMyeloid neoplasms with eosinophilia and abnormalities of the PDGFRA gene can benefit from therapy with tyrosine kinase inhibitors, therefore revealing the PDGFRA rearrangement is essential to ensure the best choice of treatment. The most common PDGFRA partner is the FIP1L1 gene, gen...
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
Washington University investigators at Siteman Cancer Center at Barnes-Jewish Hospital and the School of Medicine have been awarded a $15 million grant to study the genetic changes that drive acute myeloid leukemia (AML), a deadly blood cancer. Findings from their studies may help develop more effective therapies for patients, officials said. The grant is funded by the National Cancer Institute of the National Institutes of Health. Earlier funding for AML and a gift from Alvin Siteman allowed…
Source: Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
A new report suggests targeting the Gal9/TIM3-axis could help boost chances of complete remission in patients with acute myeloid leukemia.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
Introduction: Sweet syndrome (SS) is a rare syndrome presenting with painful, erythematous plaques or nodules and fevers. Subtypes of SS include malignancy-associated SS, commonly linked to acute myelogenous leukemia (AML), and medication-associated SS, associated with granulocyte colony-stimulating factor (G-CSF).
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Case: A 71-year-old male with acute myeloid leukemia (AML) on posaconazole for invasive fungal disease prophylaxis was found to have necrotic, escharred skin lesions on his bilateral forearms that developed while awaiting resolution of chemotherapy-induced neutropenia. 4-mm punch biopsies were performed through the necrotic center of each lesion and frozen sections were sent for investigation. Right forearm skin biopsy and frozen section were positive for angioinvasive fungal infection within the dermis and subcutis, which demonstrated vascular occlusion by numerous fungal hyphae.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Authors: Shallis RM, Bewersdorf JP, Boddu PC, Zeidan AM Abstract Introduction: The Hedgehog (HH) pathway constitutes a collection of signaling molecules which critically influence embryogenesis. In adults, however, the HH pathway remains integral to the proliferation, maintenance, and apoptosis of adult stem cells including hematopoietic stem cells. Areas covered: We discuss the current understanding of the HH pathway as it relates to normal hematopoiesis, the pathology of acute myeloid leukemia (AML), the rationale for and data from combination therapies including HH pathway inhibitors, and ultimately the prospect...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
Authors: Hemsing AL, Hovland R, Tsykunova G, Reikvam H Abstract Introduction: Trisomy 8 is one of the most common cytogenetic alterations in acute myeloid leukemia (AML), with a frequency between 10% and 15%. Areas covered: The authors summarize the latest research regarding biological, translational and clinical aspects of trisomy 8 in AML. Expert opinion: Trisomy 8 can be found together with other karyotypes, although it also occurs as sole aberration. The last decade's research has brought attention to molecular genetic alterations as strong contributors of leukemogenesis. AML with trisomy 8 seems to be associat...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
Future Oncology, Ahead of Print.
Source: Future Oncology - Category: Cancer & Oncology Authors: Source Type: research
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