A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry for the analysis of ginsenosides from white and red ginsengs

Publication date: Available online 21 September 2018Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi XuAbstractHere, time-decoupled comprehensive two-dimensional ultra-high liquid chromatography (UHPLC) coupled with an ion mobility (IM)-high resolution mass spectrometer (HRMS) was established and used to analyze ginsenosides from the main roots of white ginseng (WG) and red ginseng (RG), which enabled the separation of complex samples in four dimensions (2D-LC, ion mobility, and mass spectrometry). The incompatibility of mobile phases, dilution effect, and long analysis time, which are the main shortcomings of traditional comprehensive 2D-LC methods, were largely avoided in this newly established 2D-UHPLC method. The orthogonality of this system was 55%, and the peak capacity was 4392. Under the optimized 2D-UHPLC-IM-MS method, 201 ginsenosides were detected from white and red ginseng samples. Among them, 10 pairs of co-eluting isobaric ginseng saponins that were not resolved by 2D-UHPLC-HRMS were further resolved using 2D-UHPLC-IM-MS. In addition, 24 ginsenoside references were analyzed by UHPLC-IM-MS to obtain their collision cross section (CCS) values and ion mobility characteristics. Finally, the established new method combined with multivariate statistical analysis was successfully applied to differentiate WG and RG, and 9 ginsenosides...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research

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ConclusionsTreating physicians should include vascular malformations in differential diagnosis regarding bone tumors. A non-invasive angiographic method could be included in the preoperative work-up.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
27 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2019/11/13PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Source: Ann Oncol - Category: Cancer & Oncology Tags: Report Source Type: research
Publication date: February 2020Source: Journal of Experimental Child Psychology, Volume 190Author(s): Rachel C. Croce, Janet J. BoseovskiAbstractResearch indicates that children often show a positivity bias, or a tendency to favor positive information over negative information, in assessments of informant credibility in social and nonsocial situations. The current study investigated whether young children prioritize positive informant traits (i.e., nice vs. mean informant) as compared with positive speech content (i.e., positive vs. negative evaluation) in conflicting assessments of a work product. A total of 123 4- to 8-y...
Source: Journal of Experimental Child Psychology - Category: Child Development Source Type: research
This study investigates the following question: how does development – specifically socioeconomic and gender equity indicators – affect women’s share of enrollment in specific STEM and STEM-related fields? Merging two sources of national data, we leverage provincial census figures and institutional administrative data to estimate women's enrollment share in STEM as well as in specific fields (i.e., accounting, information technology, and health). Findings show women’s share of STEM and information technology majors is larger outside the capital. Further, socioeconomic development and urbanization in...
Source: International Journal of Educational Development - Category: Child Development Source Type: research
ConclusionsSocial media monitoring has potential for use in identifying individuals at-risk for substance abuse and those who may be perpetuating unhealthy substance use norms.
Source: Journal of Adolescence - Category: Child Development Source Type: research
Publication date: January–February 2020Source: Journal of Applied Developmental Psychology, Volume 66Author(s): Katharine Bailey, Nancie Im-BolterAbstractThe current study investigated contributors to social perspective taking during social problem solving in younger (M = 8.20, n = 111) and older (M = 12.05, n = 112) school-aged children. Results indicated a developmental progression in social perspective taking for different aspects of social problem solving. The findings suggest that social perspective taking is more difficult for some aspects of social problem solving than others. Moreover, syntact...
Source: Journal of Applied Developmental Psychology - Category: Child Development Source Type: research
Publication date: January 2020Source: Trends in Food Science &Technology, Volume 95Author(s): Ali Atamaleki, Mohsen Sadani, Amir Raoofi, Ali Miri, Saeed Gharibian Bajestani, Yadolah Fakhri, Zoha Heidarinejad, Amin Mousavi KhaneghahAbstractBackgroundThere is an increasing trend in the consumption of egg on a worldwide scale, however, it can be a source of potentially toxic elements (PTEs) which could threaten the health of consumers.Scope and approachThe related studies on the concentration of PTEs in eggs by databases including PubMed, Scopus, Web of Science and Embase in a global scale were retrieved and following met...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
In conclusion, Germany shows itself to be only moderately prepared to accept cultured meat.
Source: Meat Science - Category: Food Science Source Type: research
The objective of this study was to investigate the levels of bioactive amines in eight fresh edible commercial mushrooms species. An ion-pair HPLC method with post-column derivatization with o-phthalaldehyde and fluorescence detection was fit for the purpose. Seven out of nine amines were present and levels varied among species. Spermidine was ubiquitous to mushrooms, with highest content in Black Shimeji (12.4 mg/100 g). The levels of spermidine in mushrooms classify them as high polyamines sources, which is valued due to its association with growth, health promotion and antioxidant properties. Agmatine was ...
Source: Journal of Food Composition and Analysis - Category: Food Science Source Type: research
Publication date: Available online 12 November 2019Source: Journal of Food Composition and AnalysisAuthor(s): Larissa São Bernardo Carvalho, Caroline Santos da Silva, Joaquim Araújo Nóbrega, Elane Santos Boa Morte, Daniele Cristina Muniz Batista Santos, Maria Graças Andrade KornAbstractThis paper presents the use of microwave induced plasma optical emission spectrometry (MIP OES) for food analysis. A method for determination of Cu, K, Mg, Mn, P, and Zn in instant soups by MIP OES with N2 plasma was developed. Sample preparation procedure consisted of microwave-assisted digestion with dilute nitr...
Source: Journal of Food Composition and Analysis - Category: Food Science Source Type: research
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