The blind leading the not so blind: a meta-analysis of blinding in pharmacological trials for chronic pain

Randomised controlled trials (RCTs) are the cornerstone of evidence-based interventions both for chronic pain and medicine more generally. In particular, double-blind placebo-controlled RCTs have been heavily relied upon to determine treatment efficacy and safety of chronic pain interventions. Hundreds of double-blind placebo-controlled RCTs are run each year worldwide to test various interventions for chronic pain, with hundreds of thousands of people with chronic pain participating in these trials.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research