Tc toxin activation requires unfolding and refolding of a β-propeller

Tc toxin activation requires unfolding and refolding of a β-propellerTc toxin activation requires unfolding and refolding of a β-propeller, Published online: 19 September 2018; doi:10.1038/s41586-018-0556-6A high-resolution cryo-electron microscopy structure of a complete Tc holotoxin complex reveals the precise mechanism of Tc toxin assembly, gate opening and release of the cytotoxic enzyme into the translocation channel.

Source: Nature AOP - September 19, 2018 Category: Research Authors: Christos Gatsogiannis Felipe Merino Daniel Roderer David Balchin Evelyn Schubert Anne Kuhlee Manajit Hayer-Hartl Stefan Raunser Source Type: research