Effects of prophage regions in a plasmid carrying a carbapenemase gene on survival against antibiotic stress

In gram-negative bacteria, carbapenem resistance is primarily mediated by the production of carbapenemases hydrolyzing the β-lactam ring of carbapenem antibiotics. Since the first identification in Klebsiella pneumoniae, the blaNDM-1 gene has been detected in a wide range of bacterial species in many countries worldwide [1,2]. Generally, blaNDM is carried by a plasmid and is horizontally transferred within and between species, contributing to the rapid dissemination of NDM-producing pathogens [3].
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Tags: Short Communication Source Type: research