Proinflammatory Cytokine and Adipokine Levels in Adult Unrelated Marrow Donors Are Not Associated with Hematopoietic Cell Transplantation Outcomes

Use of allogeneic hematopoietic cell transplantation (allo-HCT) has increased dramatically over the last 3 decades and is now considered a potentially curative therapy for multiple malignant and nonmalignant diseases [1]. Despite the potential for long-term cure, allo-HCT is associated with significant risks for morbidity and mortality. One of the most frequent complications is graft-versus-host disease (GVHD), which is driven by a cascade of conditioning-induced tissue injury, proinflammatory cytokines, and activation of donor immune cells that recognize host tissue alloantigens, all culminating in tissue destruction by donor T cells [2,3].

Source: Biology of Blood and Marrow Transplantation - August 22, 2018 Category: Hematology Authors: Lucie M. Turcotte, Tao Wang, Michael T. Hemmer, Stephen R. Spellman, Mukta Arora, Ashley Yingst, Daniel Couriel, Amin Alousi, Joseph Pidala, Jennifer M. Knight, Michael R. Verneris Source Type: research