Structure Analysis of Transposons Carrying aac(6 ’)-aph(2’’) Gene in Enterococcus faecalis Isolated in Beijing China and Comparison of Their Transfer Efficiency

Enterococcus faecalis, the most clinical relevant isolate in Enterococcus group, is increasingly recognized as an important cause of nosocomial infections, especially in intensive care units. Severe enterococcal infections are usually treated by combination use of a cell wall active agent ( β-lactam or vancomycin) with aminoglycoside (typically gentamicin). However, this synergistic bactericidal activity was abolished by the emergence of High-Level Gentamicin Resistance (HLGR). Enterococcus faecalis with HLGR was first reported clinically in France in 1979 [1], and was quickly followe d by numerous reports from a diversity of geographical areas [2-8].

Source: International Journal of Antimicrobial Agents - September 5, 2018 Category: Drugs & Pharmacology Authors: Jian-Mei Zhang, Qing Wang, Tong-Yan Han, Jian-Hua Liu, Xin-Xin Hu, Feng Qiao, Xin-Yi Yang, Cong-Ran Li, Xue-Fu You Source Type: research