Infectious Mononucleosis and Lyme Disease as Confounding Diagnoses: A Report of 2 Cases.
We describe the clinical presentation of two children with confirmed early Lyme disease and features suggestive of infectious mononucleosis, including one case of probable Lyme and EBV co-infection. PMID: 30166498 [PubMed - as supplied by publisher]
Publication date: Available online 1 July 2020Source: Ticks and Tick-borne DiseasesAuthor(s): Saied Reza Naddaf, Ahmad Mahmoudi, Ahmad Ghasemi, Mahdi Rohani, Ali Mohammadi, Seyyed Payman Ziapour, Amir Hesam Nemati, Ehsan Mostafavi
Conclusion: Our data demonstrate that HBc149 chimeric VLPs provide a valuable platform to present EBV gp350 antigens and offer a robust basis for the development of peptide-based candidate vaccines against EBV.
Pathogen specific antibody responses need to be tightly regulated to generate protective but limit self-reactive immune responses. While loss of humoral tolerance has been associated with microbial infections, the pathways involved in balancing protective versus autoreactive antibody responses in humans are incompletely understood. Studies in classical mouse model systems have provided evidence that balancing of immune responses through inhibitory receptors is an important quality control checkpoint. Genetic differences between inbred mouse models and the outbred human population and allelic receptor variants not present i...
Publication date: Available online 30 June 2020Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Talita Antonia Furtado Monteiro, Iran Barros Costa, Igor Brasil Costa, Thais Letícia dos Santos Corrêa, Beatriz Monteiro Rodrigues Coelho, Amanda Emanuelle Santos Silva, Francisco Lúzio de Paula Ramos, Arnaldo Jorge Martins Filho, José Luiz Furtado Monteiro, Jones Anderson Monteiro Siqueira, Yvone Benchimol Gabbay, Rita Catarina Medeiros Sousa
This study aimed to characterize the EBV genotypes of infectious mononucleosis (IM) cases in the metropolitan region of Belém, Brazil, from 2005 to 2016. A total of 8295 suspected cases with symptoms/signs of IM were investigated by infectious disease physicians at Evandro Chagas Institute, Health Care Service, from January 2005 to December 2016. Out of the total, 1645 (19.8%) samples had positive results for EBV by enzyme immunoassay and 251 (15.3%) were submitted to polymerase chain reaction (PCR) technique, using the EBNA3C region, in order to determine the type of EBV. Biochemical testing involving aspartate ami...
Title: What Happens if You Go Untreated for Lyme Disease?Category: Diseases and ConditionsCreated: 6/17/2020 12:00:00 AMLast Editorial Review: 6/29/2020 12:00:00 AM
LOW SEROPREVALENCE OF LYME DISEASE AMONG MULTIPLE SCLEROSIS PATIENTS IN NEW BRUNSWICK. Can J Neurol Sci. 2020 Jun 29;:1-11 Authors: MacLean G, Cook P, Lindsay LR, Hatchette TF, Webster D PMID: 32594964 [PubMed - as supplied by publisher]
We report a case of septic shock in an adolescent from pelvic inflammatory disease caused by Fusobacterium necrophorum following sexual intercourse during recovery from IM.
Disseminated Lyme disease can be difficult to diagnose, as it begins with nonspecific signs and symptoms, which, if not treated correctly, can lead to atrioventricular conduction blocks and meningitis. In addition, the diagnosis can be further complicated by potentially false-positive test results.
This article describes the treatment completion rate for latent tuberculosis infections at a health clinic in Edmonton, Alberta, including an assessment of the correlates of noncompletion as well as potential means to improve treatment adherence. Effects of breakpoint changes on carbapenem susceptibility rates of Enterobacteriaceae: Results from the SENTRY Antimicrobial Surveillance Program (United States, 2008 to 2012)Antibiotic susceptibility breakpoints are determined at the time of clinical approval for a given drug, but may need to be revised to incorporate additional evidence obtained after approval of the drug. The ...