Effects of anorexia nervosa on bone metabolism.

Effects of anorexia nervosa on bone metabolism. Endocr Rev. 2018 Aug 27;: Authors: Fazeli PK, Klibanski A Abstract Anorexia nervosa is a psychiatric disease characterized by a low-weight state due to self-induced starvation. This disorder, which predominantly affects women, is associated with hormonal adaptations which minimize energy expenditure in the setting of low nutrient intake. These adaptations include growth hormone resistance, functional hypothalamic amenorrhea and non-thyroidal illness syndrome. Although these adaptations may be beneficial to short-term survival, they contribute to the significant and often persistent morbidity associated with this disorder, including bone loss which affects over 85% of women. We will review the hormonal adaptions to undernutrition, review hormonal treatments that have been studied for both the underlying disorder as well as for the associated decreased bone mass, and discuss the important challenges that remain for the treatment of bone loss in anorexia nervosa, including the lack of long-term treatments for bone loss in this chronic disorder and the fact that despite recovery, many individuals who experience bone loss as adolescents have chronic deficits and an increased risk of fracture in adulthood. PMID: 30165608 [PubMed - as supplied by publisher]
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research