The NR4A receptors Nurr1 and Nur77 are increased in human placenta from women with gestational diabetes

Discussion: Nurr1 and Nur77, which were increased in human placenta from women with GDM, are involved in TNF-α induced-expression of pro-inflammatory cytokines. Pro-inflammatory cytokines are known to play a role in placental nutrient transport. Thus, the regulation of pro-inflammatory cytokines by Nurr1 and Nur77 suggest that these proteins may play a role in placental function and transport mechanisms.Highlights:
Source: Placenta - Category: Reproduction Medicine Authors: Tags: Gene expression Source Type: research