Optimizing pH-sensitive and time-dependent polymer formula of colonic pH-responsive pellets to achieve precise drug release

In conclusion, ES100-ERS NCO colonic delivery system achieved reduced coating thickness and improved colonic targeting compared with traditional delivery system (ERS-ES100 TCO). In addition, the similarity factors (f2) value of sophoridine and matrine for investigated formulation were within 50-100 and> 80, demonstrating that sophoridine and matrine in all formulations achieved a synchronous release.Graphical abstractTASA(total alkaloids of sophora alopecuroides) pH-sensitive and time-dependent pellets were prepared by extrusion-spheronization coating with Eudragit RS30D and Eudragit S100. In order to achieve precise colon targeting effect,the in vitro release of different coating prescriptions were investigated to optimize the traditional coating method.
Source: Asian Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Source Type: research