Is Pretreatment Blood Pressure a Marker of Prazosin Response in Posttraumatic Stress Disorder With Comorbid Alcohol Use Disorder?

Posttraumatic stress disorder (PTSD) is a disabling psychiatric disorder, and central nervous system adrenergic system hyperactivity is thought to play a key role in its pathophysiology (1 –3). Several studies have suggested that prazosin, an α1-adrenoreceptor blocker, is effective in improving PTSD-related sleep symptoms, hyperarousal, global clinical status, and overall PTSD symptom burden (3–9). However, there is a wide variation in the effect(s) of prazosin across various pat ient populations (3).
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Correspondence Source Type: research