TREM2 deficiency increases plasma cholesterol and triglyceride levels without influencing lesion formation in LDLR-deficient mice

Aim: Triggering receptor expressed on myeloid cells 2 (Trem2) is a modulatory receptor on the surface of macrophages and immature dendritic cells with yet unknown ligands. Functionally, Trem2 has been suggested to both promote phagocytosis and suppress the secretion of TLR-induced inflammatory cytokines. However, recent studies demonstrated an attenuated inflammatory reaction following stroke in Trem2-deficient mice. Here, we sought to evaluate the effect of Trem2 deficiency on atherosclerotic lesion formation.

Source: Atherosclerosis - August 1, 2018 Category: Cardiology Authors: M. Kiss, F.S. Porsch, A. Hladik, L. G öderle, O. Sharif, S. Knapp, C.J. Binder Source Type: research