SAR405, a highly specific Vps34 inhibitor, disrupts auditory fear memory consolidation of mice via facilitation of inhibitory neurotransmission in basolateral amygdala

Autophagy has been demonstrated to play an important role in memory deficits as well as the degradation of neurotransmitter receptors. SAR405 is a newly discovered inhibitor that can specifically inhibit vacuolar sorting protein 34 (Vps34) and prevent autophagosome biogenesis. However, the effects of SAR405 on memory process remains largely unknown.

Source: Biological Psychiatry - August 16, 2018 Category: Psychiatry Authors: Kuan Li, Hong-Sheng Chen, Di Li, Hou-Hong Li, Ji Wang, Lei Jia, Peng-Fei Wu, Li-Hong Long, Zhuang-Li Hu, Jian-Guo Chen, Fang Wang Tags: Archival Report Source Type: research