[ASAP] Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( < italic toggle="yes" > S < /italic > )-2,2-Difluorocyclopropyl)((1 < italic toggle="yes" > R < /italic > ,5 < italic toggle="yes" > S < /italic > )-3-(2-((1-methyl-1 < italic toggle="yes" > H < /italic > -pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00917

Source: Journal of Medicinal Chemistry - August 16, 2018 Category: Chemistry Authors: Andrew Fensome, Catherine M. Ambler, Eric Arnold, Mary Ellen Banker, Matthew F. Brown, Jill Chrencik, James D. Clark, Martin E. Dowty, Ivan V. Efremov, Andrew Flick, Brian S. Gerstenberger, Ariamala Gopalsamy, Matthew M. Hayward, Martin Hegen, Brett D. Ho Source Type: research