Dismissal of RNA Polymerase II Underlies a Large Ligand-Induced Enhancer Decommissioning Program

Tan et  al. discover a mechanism underlying repression of a large basally active estrogen-repressed (BAER) enhancer program. The expression of these basally active genes in human breast cancer cells is repressed by estrogen, and the indirectly bound ERα (in trans) at BAER enhancers dismisses RNA Pol II to abrogate large, eRNA-producing enhancer programs.

Source: Molecular Cell - August 16, 2018 Category: Cytology Authors: Yuliang Tan, Chunyu Jin, Wubin Ma, Yiren Hu, Bogdan Tanasa, Soohwan Oh, Amir Gamliel, Qi Ma, Lu Yao, Jie Zhang, Kenny Ohgi, Wen Liu, Aneel K. Aggarwal, Michael G. Rosenfeld Tags: Article Source Type: research