Molecules, Vol. 23, Pages 2013: Development of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes: Synthesis and Biological Activity Evaluations

Molecules, Vol. 23, Pages 2013: Development of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes: Synthesis and Biological Activity Evaluations
Molecules doi: 10.3390/molecules23082013
Authors:
Ricardo A. Murcia
Sandra M. Leal
Martha V. Roa
Edgar Nagles
Alvaro Muñoz-Castro
John J. Hurtado

In this work, six complexes (2–7) of Cr(III) and Co(II) transition metals with triazole ligands were synthesized and characterized. In addition, a new ligand, 3,5-bis(1,2,4-triazol-1-ylmethyl)toluene (1), was synthesized and full characterized. The complexes were obtained as air-stable solids and characterized by melting point, electrical conductivity, thermogravimetric analysis, and Raman, infrared and ultraviolet/visible spectroscopy. The analyses and spectral data showed that complexes 3–7 had 1:1 (M:L) stoichiometries and octahedral geometries, while 2 had a 1:2 (M:L) ratio, which was supported by DFT calculations. The complexes and their respective ligands were evaluated against bacterial and fungal strains with clinical relevance. All the complexes showed higher antibacterial and antifungal activities than the free ligands. The complexes were more active against fungi than against bacteria. The activities of the chromium complexes against Candida tropicalis are of great interest, as they showed minimum inhibitory concentration 50 (MIC50) values between 7.8 and 15.6 μg mL−1. Complexes 5 an...

Source: Molecules - August 13, 2018 Category: Chemistry Authors: Ricardo A. Murcia Sandra M. Leal Martha V. Roa Edgar Nagles Alvaro Mu ñoz-Castro John J. Hurtado Tags: Article Source Type: research