Candidate susceptibility variants in angioimmunoblastic T-cell lymphoma

AbstractAngioimmunoblastic T-cell lymphoma (AITL) is a subtype of peripheral T-cell lymphoma with a poor prognosis: the 5-year survival rate is approximately 30%. Somatic driver mutations have been found inTET2, IDH2, DNMT3A, RHOA, FYN, PLCG1, andCD28, whereas germline susceptibility to AITL has to our knowledge not been studied. The homogenous Finnish population is well suited for studies on genetic predisposition. Here, we performed an exome-wide rare variant analysis in 23 AITL patients. No germline mutations were found in the driver genes, implying that they are not frequently involved in genetic AITL predisposition. Potentially pathogenic variants present in at least two patients and showing significant (p  <  0.01) enrichment in our sample set were found in ten genes:POLK, PRKCB, ZNF676, PRRC2B, PCDHGB6, GNL3L, TTC36, OTOG, OSGEPL1, andRASSF9. The most significantly enriched variants, causing p.Lys469Ter in a splice variant ofPOLK and p.Pro588His inPRKCB, are intriguing candidates as Polk deficient mice display a spontaneous mutator phenotype, whereasPRKCB was recently shown to be somatically mutated in 33% of another peripheral T-cell lymphoma, adult T-cell lymphoma. If validated, our findings would provide new insight into the pathogenesis of AITL, as well as tools for early detection in susceptible individuals.
Source: Familial Cancer - Category: Cancer & Oncology Source Type: research