ASK1/p38 signalling in renal tubular epithelial cells promotes renal fibrosis in the mouse obstructed kidney.

In conclusion, ASK1 is an important upstream activator of p38 and JNK signalling in the obstructed kidney, and ASK1 as a potential therapeutic target in renal fibrosis.
PMID: 25298527 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - October 8, 2014 Category: Urology & Nephrology Authors: Ma FY, Tesch GH, Nikolic-Paterson DJ Tags: Am J Physiol Renal Physiol Source Type: research