Tsix-Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function [Medical Sciences]

Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by a mutation in the X-linked methyl-CpG-binding protein 2 (MECP2). There is currently no disease-specific treatment, but MECP2 restoration through reactivation of the inactive X (Xi) has been of considerable interest. Progress toward an Xi-reactivation therapy has been hampered by a...

Source: Proceedings of the National Academy of Sciences - August 7, 2018 Category: Science Authors: Lieselot L. G. Carrette, Roy Blum, Weiyuan Ma, Raymond J. Kelleher III, Jeannie T. Lee Tags: Biological Sciences Source Type: research